Synonyms: Trazodone Hcl;(Trazodone
Appearance: white powder
What is trazodone?
Trazodone is an antidepressant medicine. It affects chemicals in
the brain that may be unbalanced in people with depression. It is a
Trazodone is used to treat major depressive disorder.
Usage & Effect:
The primary use of trazodone is the treatment of major depression.
Data from open and double-blind trials suggest the antidepressant
efficacy of trazodone is comparable to that of amitriptyline,
doxepin, and mianserin. Also, trazodone showed anxiolytic
properties, low cardiotoxicity, and relatively mild side effects.
Because trazodone has minimal anticholinergic activity, it was
especially welcomed as a treatment for geriatric patients with
depression when it first became available. Three double-blind
studies reported trazodone has antidepressant efficacy similar to
that of other antidepressants in geriatric patients. However, a
side effect of trazodone, orthostatic hypotension, which may cause
dizziness and increase the risk of falling, can have devastating
consequences for elderly patients; thus, this side effect, along
with sedation, often makes trazodone less acceptable for this
population, compared with newer compounds that share its lack of
anticholinergic activity but not the rest of its side-effect
profile. Still, trazodone is often helpful for geriatric patients
with depression who have severe agitation and insomnia.
Trazodone has also been reported to have antianxiety properties. In
a randomized, double-blind, placebo-controlled trial, the
anxiolytic efficacy of trazodone was comparable to that of diazepam
in weeks 3-8 of treatment for generalized anxiety disorder,
although patients treated with diazepam had greater improvement
during the first 2 weeks of treatment. Early case reports had
indicated that trazodone is associated with improvement in
obsessive-compulsive disorder, but a double-blind,
placebo-controlled study found that trazodone lacked
antiobsessional effects. Many clinicians use low-dose trazodone as
an alternative to benzodiazepines for the treatment of insomnia.
|CJC-1295 with DAC||2mg/vial,10vials/kit|
|CJC-1295 without DAC||2mg/vial,10vials/kit|
|pentadecapeptide BPC 157||2mg/vial,10vials/kit|