Huperzine A is a naturally occurring sesquiterpene alkaloid
compound found in the firmoss Huperzia serrata and in varying
quantities in other Huperzia species, including H. elmeri, H.
carinat, and H. aqualupian. It is known as an acetylcholinesterase
inhibitor, which means that it stops an enzyme from breaking down
acetylcholine which results in increases in acetylcholine.
Huperzine A has been investigated as a possible treatment for
diseases characterized by neurodegeneration, particularly
Alzheimer's disease. Huperzine A is also marketed as a dietary
supplement with claims made for its ability to improve memory and
mental function. Huperzine A has also been postulated as a
potential treatment for myasthenia gravis.
Huperzine A is a cognitive enhancer that inhibits an enzyme that
degrades the learning neurotransmitter, acetylcholine; due to this,
a relative increase occurs. It belongs to the cholinergics class of
molecules, and may be useful in fighting cognitive decline in the
elderly. May need to be cycled.
While Huperzine A will have an effect on its own, stacking it with
the right components may yield even better results.
Taking Huperzine A in combination with a choline source such as
Alpha GPC can increase the amount of acetylcholine in the brain
further, enhancing the effect of huperzine A.
A racetam is also a good choice for stacking with huperzine A.
Racetams are thought to activate glutamate receptors that are
located near acetylcholine receptors. This activity sensitizes the
acetylcholine receptors so they are more likely to become
activated. Sensitizing the receptors with a racetam and increasing
the amount of acetylcholine with huperzine A enhances the nootropic
effect of both drugs.
Huperzine A is also often paired with Noopept, a powerful and
For improving memory in young people, Huperzine A can be taken at
100 mg twice a day. It has been used at 50 to 200 mcg twice a day
to treat Alzheimer's disease. We suggest that regular users take a
break from the drug every few weeks to avoid physical habituation.
For example, after taking huperzine A daily for three weeks,
consider cycling off of it for one week before resuming regular
Huperzine A does not need to be taken with food. It is quickly
absorbed into the body and will begin to enhance memory
immediately. It has a very long half-life in the body, and a single
dose will provide benefits for over 24 hours. The drug has been
shown to be quite capable of passing the blood-brain barrier after
oral ingestion and quickly accumulates in the cerebrospinal fluid.
If you stick to the recommended dosage, Huperzine A is considered
to be very safe with low risk of side effects. Some mild bad
reactions have occurred resulting in side effects such as nausea,
vomiting, appetite suppression, restlessness, headaches, high blood
pressure and increased sweating.